Synthesis of 8-aminoquinoline chelating moieties for chemosensor molecules
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چکیده
منابع مشابه
Antimalarials with Benzothiophene Moieties as Aminoquinoline Partners.
Malaria is a severe and life-threatening disease caused by Plasmodium parasites that are spread to humans through bites of infected Anopheles mosquitoes. Here, we report on the efficacy of aminoquinolines coupled to benzothiophene and thiophene rings in inhibiting Plasmodium falciparum parasite growth. Synthesized compounds were evaluated for their antimalarial activity and toxicity, in vitro a...
متن کاملPrimaquine or other 8-aminoquinoline for reducing P. falciparum transmission
BACKGROUND Mosquitoes become infected with Plasmodium when they ingest gametocyte-stage parasites from an infected person's blood. Plasmodium falciparum gametocytes are sensitive to the drug primaquine (PQ) and other 8-aminoquinolines (8AQ); these drugs could prevent parasite transmission from infected people to mosquitoes, and consequently reduce the incidence of malaria. However, PQ will not ...
متن کاملElectrochemistry of ruthenium(II) complexes of 8-aminoquinoline.
Oxidation of [Ru(NH(2)Q)(3)](2+) (NH(2)Q = 8-aminoquinoline) results in intermolecular coupling of 8-aminoquinoline ligands to yield an electroactive polymer. Oxidative polymerization is not observed for [Ru(bpy)(2)(NH(2)Q)](2+) (bpy = 2,2'-bipyridine), where only one 8-aminoquinoline ligand is present.
متن کاملAntileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine.
The 8-aminoquinoline tafenoquine showed significant in vitro activity against Leishmania species, including L. donovani amastigotes in macrophages, with 50% inhibitory concentrations (IC(50)s) between 0.1 and 4.0 μM for both pentavalent antimony (SbV)-sensitive and SbV-resistant strains and by oral administration in BALB/c mice, with 50% effective dose (ED(50)) values of 1.2 to 3.5 mg/kg for 5 ...
متن کاملSynthesis of Novel Bis-Benzimidazolyl Podands: A new Chemosensor for Cu2+
Some new compounds based on bis-benzimidazole moieties have been synthesized and characterized by IR and NMR spectroscopies. The ability of 3a in transition metal cation sensing such as Co2+, Ni2+, Zn2+, Mn2+, Fe2+ and Cu2+ have been investigated by Uv-vis and fluorescence spectroscopy in methanol solvent. The complexation constants and complex stoichiometry of Cu2+ have been determined. The ex...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2022
ISSN: ['1551-7012', '1551-7004']
DOI: https://doi.org/10.24820/ark.5550190.p011.746